G. Gerig, I. Oguz, S. Gouttard, J. Lee, H. An, W. Lin, M. McMurray, K. Grewen, J. Johns, M.A. Styner.
Synergy of image analysis for animal and human neuroimaging supports translational research on drug abuse, In Frontiers in Child and Neurodevelopmental Psychiatry, Vol. 2, Edited by Linda Mayes, pp. 9 pages. 2011.
Encyclopedia on Early Childhood Development (online): Brain Development in Children - According to Experts, Montreal, Quebec, Centre of Excellence for Early Childhood Development and Strategic Knowledge Cluster on Early Child Development, pp. 1--6. 2011.G. Gerig, J.H. Gilmore, W. Lin. Brain Maturation of Newborns and Infants,
Recently, imaging studies of early human development have received more attention, as improved modeling methods might lead to a clearer understanding of the origin, timing, and nature of differences in neurodevelopmental disorders. Non-invasive magnetic resonance imaging (MRI) can provide three-dimensional images of the infant brain in less than 20 minutes, with unprecedented anatomical details and contrast of brain anatomy, cortical and subcortical structures and brain connectivity. Repeating MRI at different stages of development, e.g., in yearly intervals starting after birth, gives scientists the opportunity to study the trajectory of brain growth and compare individual growth trajectories to normative models. These comparisons become highly relevant in personalized medicine, where early diagnosis is a critical juncture for timing and therapy types.
L.K. Ha, M.W. Prastawa, G. Gerig, J.H. Gilmore, C.T. Silva.
Efficient Probabilistic and Geometric Anatomical Mapping Using Particle Mesh Approximation on GPUs, In International Journal of Biomedical Imaging, Special Issue in Parallel Computation in Medical Imaging Applications, Vol. 2011, Note: Article ID 572187, pp. 16 pages. 2011.
Although neuroimaging is essential for prompt and proper management of traumatic brain injury (TBI), there is a regrettable and acute lack of robust methods for the visualization and assessment of TBI pathophysiology, especially for of the purpose of improving clinical outcome metrics. Until now, the application of automatic segmentation algorithms to TBI in a clinical setting has remained an elusive goal because existing methods have, for the most part, been insufficiently robust to faithfully capture TBI-related changes in brain anatomy. This article introduces and illustrates the combined use of multimodal TBI segmentation and time point comparison using 3D Slicer, a widely-used software environment whose TBI data processing solutions are openly available. For three representative TBI cases, semi-automatic tissue classification and 3D model generation are performed to perform intra-patient time point comparison of TBI using multimodal volumetrics and clinical atrophy measures. Identification and quantitative assessment of extra- and intra-cortical bleeding, lesions, edema, and diffuse axonal injury are demonstrated. The proposed tools allow cross-correlation of multimodal metrics from structural imaging (e.g., structural volume, atrophy measurements) with clinical outcome variables and other potential factors predictive of recovery. In addition, the workflows described are suitable for TBI clinical practice and patient monitoring, particularly for assessing damage extent and for the measurement of neuroanatomical change over time. With knowledge of general location, extent, and degree of change, such metrics can be associated with clinical measures and subsequently used to suggest viable treatment options.
R.C. Knickmeyer, C. Kang, S. Woolson, K.J. Smith, R.M. Hamer, W. Lin, G. Gerig, M. Styner, J.H. Gilmore.
Twin-Singleton Differences in Neonatal Brain Structure, In Twin Research and Human Genetics, Vol. 14, No. 3, pp. 268--276. 2011.
A population growth model that represents the growth trajectories of individual subjects is critical to study and understand neurodevelopment. This paper presents a framework for jointly estimating and modeling individual and population growth trajectories, and determining significant regional differences in growth pattern characteristics applied to longitudinal neuroimaging data. We use non-linear mixed effect modeling where temporal change is modeled by the Gompertz function. The Gompertz function uses intuitive parameters related to delay, rate of change, and expected asymptotic value; all descriptive measures which can answer clinical questions related to growth. Our proposed framework combines nonlinear modeling of individual trajectories, population analysis, and testing for regional differences. We apply this framework to the study of early maturation in white matter regions as measured with diffusion tensor imaging (DTI). Regional differences between anatomical regions of interest that are known to mature differently are analyzed and quantified. Experiments with image data from a large ongoing clinical study show that our framework provides descriptive, quantitative information on growth trajectories that can be directly interpreted by clinicians. To our knowledge, this is the first longitudinal analysis of growth functions to explain the trajectory of early brain maturation as it is represented in DTI.
Y. Wang, A. Gupta, Z. Liu, H. Zhang, M.L. Escolar, J.H. Gilmore, S. Gouttard, P. Fillard, E. Maltbie, G. Gerig, M. Styner.
DTI registration in atlas based fiber analysis of infantile Krabbe disease, In Neuroimage, pp. (in print). 2011.
PubMed ID: 21256236
M. El-Sayed, R.G. Steen, M.D. Poe, T.C. Bethea, G. Gerig, J. Lieberman, L. Sikich. Deficits in gray matter volume in psychotic youth with schizophrenia-spectrum disorders are not evident in psychotic youth with mood disorders, In J Psychiatry Neurosci, July, 2010.
M. El-Sayed, R.G. Steen, M.D. Poe, T.C. Bethea, G. Gerig, J. Lieberman, L. Sikich.
Brain volumes in psychotic youth with schizophrenia and mood disorders, In Journal of Psychiatry and Neuroscience, Vol. 35, No. 4, pp. 229--236. July, 2010.
PubMed ID: 20569649
J.H. Gilmore, C. Kang, D.D. Evans, H.M. Wolfe, M.D. Smith, J.A. Lieberman, W. Lin, R.M. Hamer, M. Styner, G. Gerig.
Prenatal and Neonatal Brain Structure and White Matter Maturation in Children at High Risk for Schizophrenia, In American Journal of Psychiatry, Vol. 167, No. 9, Note: Epub 2010 Jun 1, pp. 1083--1091. September, 2010.
PubMed ID: 20516153
J.H. Gilmore, J.E. Schmitt, R.C. Knickmeyer, J.K. Smith, W. Lin, M. Styner, G. Gerig, M.C. Neale.
Genetic and environmental contributions to neonatal brain structure: A twin study, In Human Brain Mapping, Vol. 31, No. 8, Note: ePub 8 Jan 2010, pp. 1174--1182. 2010.
PubMed ID: 20063301
L. Ha, M.W. Prastawa, G. Gerig, J.H. Gilmore, C.T. Silva, S. Joshi.
Image Registration Driven by Combined Probabilistic and Geometric Descriptors, In Med Image Comput Comput Assist Interv., Vol. 13, No. 2, pp. 602--609. 2010.
PubMed ID: 20879365
Deformable image registration in the presence of considerable contrast differences and large-scale size and shape changes represents a significant challenge for image registration. A representative driving application is the study of early brain development in neuroimaging, which requires co-registration of images of the same subject across time or building 4-D population atlases. Growth during the first few years of development involves significant changes in size and shape of anatomical structures but also rapid changes in tissue properties due to myelination and structuring that are reflected in the multi-modal Magnetic Resonance (MR) contrastmeasurements. We propose a new registration method that generates a mapping between brain anatomies represented as a multi-compartment model of tissue class posterior images and geometries.We transform intensity patterns into combined probabilistic and geometric descriptors that drive thematching in a diffeomorphic framework, where distances between geometries are represented using currents which does not require geometric correspondence. We show preliminary results on the registrations of neonatal brainMRIs to two-year old infantMRIs using class posteriors and surface boundaries of structures undergoing major changes. Quantitative validation demonstrates that our proposedmethod generates registrations that better preserve the consistency of anatomical structures over time.
Z. Liu, C. Goodlett, G. Gerig, M. Styner.
Evaluation of DTI Property Maps as Basis of DTI Atlas Building, In SPIE Medical Imaging, Vol. 7623, 762325, February, 2010.
Z. Liu, Y. Wang, G. Gerig, S. Gouttard, R. Tao, T. Fletcher, M.A. Styner.
Quality control of diffusion weighted images, In SPIE Medical Imaging, Vol. 7628, 76280J, February, 2010.