"Technology push" and "biomedical science pull"
The early years of the Center were marked by a desire to push technology. Recently, there has been a shift to a situation in which biomedical scientists see the potential of computing and work with the Center to pull some of that technology into specific applications in biomedicine.
We have implemented a new design that places each collaboration into a management process we call a "collaboration life cycle". The motivation for this comes from the challenge of providing adequate and appropriate attention to each of a number of parallel projects and ensuring that each progresses as it should. Our past collaborations have provided crucial guidance in directing the technical path of the Center in creating and extending BioPSE and map3d. This new approach will allow us to effectively manage a large number of quality collaborations. Our new process will allow us to adjust the level of attention the Center pays to a particular project, add new projects, and perhaps even minimize the ongoing support of a project.
The general role of the collaborators is to give focus and motivation to the Center's technological research and development. Collaborations also allow us to work with practicing scientists to develop techniques, algorithms, and software that are very well linked to their application to biomedicine. The feedback we receive from collaborators is invaluable in helping us identify the strengths and weaknesses of our approach and in ensuring efficient and effective interactions with the larger scientific community.
The Collaborative Pipeline
Driving Biological Projects
Image-Based Small-Animal Phenotyping
Collaborating Investigators: Charles Keller, MD, University of Texas Health Science Center at San Antonio
Image-based Management of Atrial Fibrillation
Collaborating Investigators: Nassir Marrouche MD, Chris McGann MD
Statistical and Biomechanical Analysis of Hip Dysplasia
Collaborating Investigators: Dr. Jeffrey Weiss, Dr. Andrew Anderson
Simulation of Electric Stimulation for Bone Growth
Collaborating Investigators: Roy Bloebaum, Brad Isaacson
Simulation of Cardiac Defibrillation
John Triedman, MD, Children's Hospital Boston
Matt Jolley, MD, Stanford University
Natalia Trayanova, John's Hopkins University
Tom Pilcher, University of Utah
Simulation of Deep Brain Stimulation
Collaborating Investigator: Christopher R. Butson, Ph.D., Medical College of Wisconsin
Bayesian Source Imaging of Pediatric Epilepsy
Collaborating Investigator: Simon Warfield, Director of the Computational Radiology Laboratory
High-Resolution Source Imaging From EEG
Collaborating Investigator: Dr. Don Tucker, Electrical Geodesics Inc. and University of Oregon
Collaborating PI: Janet Lainhart, M.D.; Mark Leppert, Ph.D.
Institution: Departments of Psychiatry and Genetrics, University of Utah
Title of Project: Image-Based, Intermediate Biological Phenotypes Associated with Autism Spectrum Disorder
Collaborating PI: Raimond Winslow, Ph.D.
Institution: Johns Hopkins University
Title of Project: Identifying and Quantifying Shape Features of Human Left Ventricular Remodeling
Collaborating PI: Martin Styner, Ph.D.
Institution: Departments of Computer Science and Psychiatry, University of North Carolina Chapel Hill
Title of Project: Cortical Correspondence Using Entropy-Based Particle Systems and Local Features
Collaborating PI: Petr Stovicek
Institution: Charles University Hospital, Prague, Czech Republic
Title of Project: Clinical Application of Electrocardiographic Inverse Solutions
Collaborating PI: Camerons McIntyre, Ph.D.
Institution: Cleveland Clinic, Lerner College of Medicine
Title of Project: Systems-Level Model of Deep Brain Simulation
Collaborating PI: Rok Hren
Institution: Institute of Mathematics, Physics and Mechanics, University of Ljubljana, Slovenia
Title of Project: Evaluation of Inverse Solution Approaches
Collaborating PI: Sinan Muftu, Associate Professor
Institution: Department of Mechanical and Industrial Engineering, Northeastern University, Boston, MA
Title of Project: Biomechanical Modeling of the Mandible and Teeth
Collaborating PI: Vasilis Ntziachristos
Institution: Technical University of Munich, Germany, Department of Mechanical and Industrial Engineering, Northeastern University, Boston, MA
Title of Project: Molecular Imaging with Individualized Priors
Collaborating PI: Charles DiMarzio
Institution: Department of Electrical and Computer Engineering
Collaborating PI: Milind Rajadyhaksha
Institution: Dermatology Service, Northeastern University, Boston, MA
Collaborating PI: Memorial Sloan
Institution: Kettering Cancer Center, New York, NY
Title of Project: Confocal Imaging of Skin and the Oral Cavity
Collaborating PI: Carsten Wolters, Ph.D.
Institution: University of Münster
Title of Project: Technical Collaboration for Brain Source Localization Software
Collaborating PI: Craig Henriquez, Ph.D.
Institution: Department of Bioengineering, Duke University
Title of Project: Integration of cardiowave and SCIRun
Collaborating PI: Leslie Loew, Ph.D., and Ion Moraru, Ph.D.
Institution: The National Resource for Cell Analysis and Modeling (NRCAM), University of Connecticut Health Center
Title of Project: Image based modeling in cell simulations
Collaborating PI: Andrew Pullan, Ph.D.
Institution: Auckland Bioengineering Institute, University of Aukland, New Zealand
Title of Project: Simulation of bioelectric fields
Collaborating PI: Joe Piven, M.D.; Heather Hazlatt, Ph.D.
Institution: Department of Psychiatry, University of North Carolina
Title of Project: Morphological analysis of neuroimages in pediatric autism
Collaborating PI: Chi-Bin Chien, Ph.D.
Institution: Department of Neurobiology and Anatomy
Title of Project: Interactive visualization of multichannel confocal microscopy data in neurobiology research
Collaborating PI: Robert Marc, Ph.D.; Bryan Jones, Ph.D.; James Anderson
Institution: Moran Eye Center, University of Utah
Title of Project: Serial section microscopy for discovering the circuitry of the mammalian retina
Collaborating PI: Matthew Tocheri
Institution: Smithsonian Institute
Title of Project: Shape-based analysis of hominid trapezia
Collaborating PI: Gregory A. Worrell, M.D., Ph.D.
Institution: Mayo Clinic Rochester and Mayo Clinic College of Medicine
Title of Project: Biomarkers of the epileptic brain
Collaborating PI: Art Toga, Ph.D.
Title of Project: Integration of SCIRun with the LONI Pipeline
Collaborating PI: Ron Kikinis, M.D.
Institution: Surgical Planning Laboratory, Harvard University
Title of Project: Volume Rendering Support for Slicer
Collaborating PI: Mark Ellisman, Ph.D.
Institution: National Center for Microscopy and Imaging Research (NCMIR)
Title of Project: EM image processing and visualization
Collaborating PI: Miriam Leeser, Ph.D.
Institution: Electrical and Computing Engineering, Northeastern University
Title of Project: Middleware layer for seamless runtime porting of SCIRun computations to streaming architecture