Rob MacLeod, Steve Poelzing, John Bridge,
Alonso Moreno, Frank Sachse, Michael Sanguinetti, Mark Warren, and John White
The goal of this class is to provide an intermediate level overview of electrophysiology and biophysics at the level of the membrane and cell to students with special interest in cardiology and neurosciences. We will develop the structural and functional characteristics at each scale with emphasis on integration across the scales. We will try to emphasize common elements of structure, function, and control that arise across the cardiovascular and nervous systems and also across species and also identify differentiating features. The approach will be a combination of qualitative explanations, quantitative analysis,laboratory experience, and mathematical simulation. The class format will include didactic lectures, group discussion of primary literature, quantitative problem solving exercises, writing assignments, and laboratory exercise. The prerequisite for the course are Bioengineering 6000, 6010, 6430, or equivalent or permission of the instructor and knowledge of university undergraduate level calculus and physics. Homework assignments will require the use of MATLAB and familiarity with internet based transfer of computer files. All course materials will be available through a web site www.sci.utah.edu/~macleod/bioen/be6003 and the class will communicate by means of an electronic mailing list (see the web page for instructions).
Class times: Monday and Wednesday, 10:45-12:15 am, labs schedule separately
Classroom: CVRTI Library/Meeting room
Credits: 3 credit-hours
| Name | Phone | Office | Hours | |
| Rob MacLeod (RM) | 5-7596 | macleod@sci.utah.edu | CVRTI/WEB | by appt. |
| Steve Poelzing (SP) | 5-1862 | poelzing@cvrti.utah.edu | CVRTI | by appt. |
| John Bridge (JB) | 7-5845 | bridge@cvrti.utah.edu | CVRTI | by appt. |
| Alonso Moreno (AM) | 7-5845 | moreno@cvrti.utah.edu | CVRTI | by appt. |
| Frank Sachse (FS) | 7-9514 | fs@cvrti.utah.edu | CVRTI | by appt. |
| Michael Sanguinetti (MS) | 1-3058 | sanguinetti@cvrti.utah.edu | CVRTI | by appt. |
| John White (JW) | 7-8347 | john.white@utah.edu | BPRB | by appt. |
| Mark Warren (MW) | 1-8183 | warren@cvrti.utah.edu | CVRTI | by appt. |
There is no required text for the class and topics will be covered with handouts or journal articles. However, the following resources provide good sources of background material:
The grade for the course will be based on some combination of homework assignments, and laboratory exercises.
| Date | Instructor | Topic | Reading |
| Week #1, Aug. 23-25 | RM | Intro and Math/Physics Background | Hille Ch. 1 |
| Week #2, Aug. 30-Sept. 1 | JW | Biophysics Background | Handout |
| September 6 | Labor Day Holiday | ||
| Week #3, Sept. 13-15 | JB | Whole cell cardiac | |
| Week #4, Sept. 20-22 | JB | EC Coupling | |
| Week #5, Sept. 27-29 | MS | Ion channel structure | |
| Week #6, Oct. 4-6 | MS | Ion channels types | |
| Oct 11-15 | Fall Break | ||
| Week #7, Oct. 18-20 | FS | Modeling of channels | |
| Week #8, Oct. 25-27 | MS | Ion channel lab | |
| Week #9, Nov 1-3 | JW | Whole cell neuron | |
| Week #10, Nov. 8-10 | JW | Neural synapse | |
| Week #11, Nov. 15-17 | RM | Whole cell modeling | |
| Week #12, Nov. 22-24 | SP & MW | Optical methods lab | |
| Nov 25-26 | Thanksgiving | ||
| Week #13, Nov. 29-Dec. 1 | AM | Cell to cell communications | |
| Week #14, Dec. 6-8 | RM & FS | Simulation lab | |
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