Bioengineering 3202 Sample Quiz


Below is an example of the kind of questions one can expect on a BE 3202 exam or quiz. Suggestions for answers are included after each questions in italics. For a final exam, there might be 10-15 of the true/false questions and 3-4 of the essay questions.


1)
Answer the following true/false questions and provide a short (1-3 sentences) explanation for each answer
  1. If there were no Ca2+ current, cardiac action potentials would be much shorter than they are.
    True: the Ca2+ current is responsible for prolong the action potential. Without it, the K+ current would dominate and bring about a premature repolarization.

  2. All types of cells in the heart contract and therefore all have T tubules.
    False: cells that make up the Purkinje fibers in the heart do not contract and also do not have T tubules. These cells are specialized for passing electrical activation and so do not have a contractile function.

  3. In humans, the size of the ECG is directly correlated with the level of exercise one is undertaking.
    False: the size or amplitude of the ECG depends on the potential difference that arises between different parts of heart and the location of the lead used to record it. There is no reason to expect exercise to significantly change the distribution of potential in the heart and hence no reason for it to increase (or decrease) ECG amplitude.

2)
Answer only ONE of the following essay questions, using from .5 to 1.5 pages for each:

  1. Explain what is meant by ``calcium loading'' in cardiac cells and the mechanisms that underly this process.
    For this question, begin with a definition of the term and then explain briefly how calcium management occurs in the heart and how an influx of Ca2+ via L-type calcium channels will lead to a rise in total Ca2+ in the cell. You might use the staircase or ``Treppe'' behavior as an example of calcium loading.

  2. Explain one mechanism that can explain the occurrence of ventricular tachycardia.
    Avoid the temptation to download everything you know even remotely related to tachycardia (a.k.a. brain-dumping) and focus instead on answering the question. Select one mechanism and go through it, using a diagram to help explain the key points of the mechanism and the resulting pattern of excitation of the ventricles. Do not describe how one might teat such an arrhythmia--that could be a separate question.

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Rob Macleod 2004-05-01