AI for Healthcare Imaging

Machine learning for radiology, pathology, and cardiology with emphasis on clinically meaningful prediction, localization, and explainability.

Healthcare imaging presents a rich but challenging setting for machine learning: clinically relevant findings may be subtle, labels can be incomplete, and deployment requires trust and interpretability. This theme develops AI methods for radiology, pathology, and cardiology that emphasize clinically aligned prediction, localization, and transparent model behavior.

We design models that integrate limited supervision, human workflow signals, and robust representation learning to improve both performance and reliability. A central goal is to produce systems that are not only accurate on benchmark tasks but also inspectable and useful in clinical decision support, where understanding model evidence and failure modes is essential.

Methods

Semi-supervised learningSelf-supervised learningWeak supervisionInterpretabilityDomain adaptation

Application Areas

RadiologyPathologyCardiology

Selected Projects

Selected Publications

Figure: Self-supervised contrastive learning enables robust electrocardiogram-based cardiac classification

Self-supervised contrastive learning enables robust electrocardiogram-based cardiac classification

Deekshith Dade, Jake A. Bergquist, Rob S. MacLeod, Benjamin A. Steinberg, Tolga Tasdizen

Heart Rhythm O2 2026

Figure: Weakly Supervised Contrastive Learning for Histopathology Patch Embeddings

Weakly Supervised Contrastive Learning for Histopathology Patch Embeddings

Bodong Zhang, Xiwen Li, Hamid Manoochehri, Xiaoya Tang, Deepika Sirohi, Beatrice S. Knudsen, Tolga Tasdizen

arXiv preprint 2026

Figure: CLASS-M: Adaptive stain separation-based contrastive learning with pseudo-labeling for histopathological image classification

CLASS-M: Adaptive stain separation-based contrastive learning with pseudo-labeling for histopathological image classification

Bodong Zhang, Hamid Manoochehri, Man Minh Ho, Fahimeh Fooladgar, Yosep Chong, Beatrice S. Knudsen, Deepika Sirohi, Tolga Tasdizen

Medical Image Analysis 2025

F2FLDM: Latent Diffusion Models with Histopathology Pre-Trained Embeddings for Unpaired Frozen Section to FFPE Translation

Man Minh Ho, Shikha Dubey, Yosep Chong, Beatrice S. Knudsen, Tolga Tasdizen

IEEE/CVF Winter Conference on Applications of Computer Vision (WACV) 2025 2025

Figure: Hierarchical Transformer for Electrocardiogram Diagnosis

Hierarchical Transformer for Electrocardiogram Diagnosis

Xiaoya Tang, Jake A. Bergquist, Benjamin A. Steinberg, Tolga Tasdizen

arXiv preprint 2024

HistoEM: A Pathologist-Guided and Explainable Workflow for Histopathological Image Analysis Using Expectation Maximization

Alessandro Ferrero, Elham Ghelichkhan, Hamid Manoochehri, Man Minh Ho, Daniel J Albertson, Benjamin J Brintz, Tolga Tasdizen, Ross T Whitaker, Beatrice S Knudsen

Modern Pathology 2024

Machine Learning Prediction of Blood Potassium at Different Time Cutoffs

Jake A. Bergquist, Deekshith Dade, Brian Zenger, Rob S. MacLeod, Xingyang Ye, Ravi Ranjan, Tolga Tasdizen, Benjamin A. Steinberg

Computing in Cardiology Conference (CinC) 2024

Performance of off-the-shelf machine learning architectures and biases in low left ventricular ejection fraction detection

Jake A. Bergquist, Brian Zenger, James Brundage, Rob S. MacLeod, T. Jared Bunch, Rashmee Shah, Xiangyang Ye, Ann Lyons, Michael Torre, Ravi Ranjan, et al.

Heart Rhythm O2 2024

Figure: Localization supervision of chest x-ray classifiers using label-specific eye-tracking annotation

Localization supervision of chest x-ray classifiers using label-specific eye-tracking annotation

Ricardo Bigolin Lanfredi, Joyce D. Schroeder, Tolga Tasdizen

Frontiers in Radiology 2023

REFLACX, a dataset of reports and eye-tracking data for localization of abnormalities in chest x-rays

Ricardo Bigolin Lanfredi, Mingyuan Zhang, William F. Auffermann, Jessica Chan, Phuong-Anh T. Duong, Vivek Srikumar, Trafton Drew, Joyce D. Schroeder, Tolga Tasdizen

Scientific Data 2022

Prediction of Obstructive Lung Disease from Chest Radiographs via Deep Learning Trained on Pulmonary Function Data

Joyce D. Schroeder, Ricardo Bigolin Lanfredi, Tao Li, Jessica Chan, Clement Vachet, Robert Paine III, Vivek Srikumar, Tolga Tasdizen

International Journal of Chronic Obstructive Pulmonary Disease 2021

Figure: Interpretation of Disease Evidence for Medical Images Using Adversarial Deformation Fields

Interpretation of Disease Evidence for Medical Images Using Adversarial Deformation Fields

Ricardo Bigolin Lanfredi, Joyce D. Schroeder, Clement Vachet, Tolga Tasdizen

MICCAI 2020 (LNCS 12262) 2020

Figure: Adversarial Regression Training for Visualizing the Progression of Chronic Obstructive Pulmonary Disease with Chest X-Rays

Adversarial Regression Training for Visualizing the Progression of Chronic Obstructive Pulmonary Disease with Chest X-Rays

Ricardo Bigolin Lanfredi, Joyce D. Schroeder, Clement Vachet, Tolga Tasdizen

MICCAI 2019 (LNCS 11769) 2019