Designed especially for neurobiologists, FluoRender is an interactive tool for multi-channel fluorescence microscopy data visualization and analysis.
Deep brain stimulation
BrainStimulator is a set of networks that are used in SCIRun to perform simulations of brain stimulation such as transcranial direct current stimulation (tDCS) and magnetic transcranial stimulation (TMS).
Developing software tools for science has always been a central vision of the SCI Institute.

Events on January 20, 2017

Terrence Sejnowski

Terrence Sejnowski, Salk Institute, Howard Hughes Medical Institute, University of California at San Diego Presents:

Space-time Computing in Dendritic Spines

January 20, 2017 at 2:00pm for 1hr
Evans Conference Room, WEB 3780
Warnock Engineering Building, 3rd floor.

Terrence Sejnowski is a pioneer in computational neuroscience and his goal is to understand the principles that link brain to behavior. His laboratory uses both experimental and modeling techniques to study the biophysical properties of synapses and neurons and the population dynamics of large networks of neurons. New computational models and new analytical tools have been developed to understand how the brain represents the world and how new representations are formed through learning algorithms for changing the synaptic strengths of connections between neurons. He has published over 300 scientific papers and 12 books, including The Computational Brain, with Patricia Churchland. He received his PhD in physics from Princeton University and was a postdoctoral fellow at Harvard Medical School. He was on the faculty at the Johns Hopkins University and he now holds the Francis Crick Chair at The Salk Institute for Biological Studies and is also a Professor of Biology at the University of California, San Diego, where he is co-director of the Institute for Neural Computation and co-director of the NSF Temporal Dynamics of Learning Center. He is the President of the Neural Information Processing Systems (NIPS) Foundation, which organizes an annual conference attended by over 1000 researchers in machine learning and neural computation and is the founding editor-in-chief of Neural Computation published by the MIT Press. An investigator with the Howard Hughes Medical Institute, he is also a Fellow of the American Association for the Advancement of Science and a Fellow of the Institute of Electrical and Electronics Engineers. He has received many honors, including the NSF Young Investigators Award, the Wright Prize for interdisciplinary research from the Harvey Mudd College, the Neural Network Pioneer Award from the Institute of Electrical and Electronics Engineers and the Hebb Prize from the International Neural Network Society. He was elected to the Institute of Medicine in 2008, to the National Academy of Sciences in 2010, and to the National Academy of Engineering in 2011. He is one of only 10 living persons to be a member of all 3 national academies.

Abstract:

Most excitatory synapses on cortical pyramidal neurons occur on the heads of dendritic spines. The function of spines is not known but they may provide chemical compartmentalization, acting as functionally autonomous computational units. We have used Monte Carlo techniques to simulate the events that occur during the induction of synaptic plasticity in spines. The results suggest that microdomains are essential for understanding how spines respond differentially to stimuli with millisecond timing differences. By carefully measuring the volumes of dendritic spines we were able to estimate a lower bound of CV = 0.08 for the precision of synaptic plasticity, corresponding to 4.7 bits of stored information.

Posted by: Deb Zemek